Profile
Peter LaCelle, Ph.D., is a distinguished scholar in the field of cell biology and dermatological research, with a longstanding affiliation with the University of Rochester School of Medicine. His expertise centers on the regulation of growth and differentiation in epidermal keratinocytes, with additional interests in photoprotection, skin cell signaling pathways, and gene expression related to skin biology. Dr. LaCelle's academic and research background includes a Ph.D. and M.S. in Physiology and Cell Biology from Albany Medical College, and a B.A. in Chemistry from Houghton College. He has served as principal investigator on multiple NIH-funded dermatology research grants and is a long-time member of professional societies including the Society for Investigative Dermatology and the American Society for Cell Biology.
Dr. LaCelle has contributed extensively to the scientific literature, with publications in respected journals such as The Journal of Biological Chemistry, The Journal of Investigative Dermatology, and Blood. His research has explored the transcriptional regulation of skin proteins like involucrin and transglutaminase, as well as the impact of UV exposure on keratinocyte behavior and gene expression. In the classroom, he brings this depth of knowledge to courses in physiology, biology, and related disciplines, inspiring students through both his academic rigor and his commitment to applied science.
Education
- Ph.D. in Physiology & Cell Biology | Albany Medical College
- M.S. in Physiology & Cell Biology | Albany Medical College
- B.A. in Chemistry | Houghton College
Sample Publications
- LaCelle, P, Blumenstock, FA, McKinley, C, Saba, TM, Vincent, PA, and Gray V. Blood-borne collagenous debris complexes with plasma fibronectin after thermal injury. Blood 75:475-478. 1990.
- LaCelle, P, Blumenstock, FA, and Saba, TM. Blood-borne fragments of fibronectin after thermal injury. Blood 77:2037-2041. 1991.
- Blumenstock, FA, LaCelle, P, Hermannsdoerfer, A, Giunta, C, Minnear, FL, Cho, E, and Saba, TM. Hepatic removal of 125I-DLT gelatin after burn injury: a model of soluble collagenous debris that interacts with plasma fibronectin. J Leukoc Biol 54(1):56-64. 1993.
- Robinson, NA, LaCelle, PT, and Eckert, RL. Involucrin is a covalently crosslinked constituent of highly purified epidermal corneocytes: evidence for a common pattern of involucrin crosslinking in vivo and in vitro. J Invest Dermatol 107:101-107, 1996.
- Efimova, T., LaCelle, P., Welter, J.F., Eckert, R.L. Regulation of human involucrin promoter activity by a protein kinase C, Ras, MEKK1, MEK3, p38/RK, AP1 signal transduction pathway. J Biol Chem 273(38):24387-24395,1998.
- LaCelle, PT, Lambert A, Ekambaram MC, Robinson NA, and Eckert, RL. In vitro cross-linking of recombinant human involucrin. Skin Pharmacol Appl Physiol 11(4-5):214-226, 1998.
- Polakowska, RR, Graf, BA, Falciano, V, LaCelle, P. Tanscription regulatory elements of the first Intron 1 control human transglutaminase type 1 gene expression in epidermal keratinocytes. J Cell Biochem 73(3):355-369, 1999.
- LaCelle, PT, and Polakowska, R. Human Homeobox HOXA7 Regulates Keratinocyte Transglutaminase Type 1 and inhibits differentiation. J Biol Chem 276(35):32844-32853, 2001.
- Tripp, CS, Blomme, EAG, Chinn, KS, Hardy, MM, LaCelle, P, and Pentland, AP. Epidermal COX-2 Induction Following UV Irradiation; Suggested Mechanism for the Role of COX-2 Inhibition in Photoprotection. J Invest Dermatol 121(4):853-861, 2003.
- LaCelle, PT, Agnello, RW, Miller, CC. Hypoxia-inducible factor-1 mediates ultraviolet B-induced keratinocyte vascular endothelial growth factor expression and antagonizes p53. J Biol Chem, Submitted, 2005.